The Side Effects of Testosterone Replacement Therapy (TRT): What to Watch Out For!

Oct 12. 2023

Testosterone Replacement Therapy (TRT) can be a game-changer for individuals dealing with low testosterone levels, offering a wide range of benefits from improved mood and energy to increased muscle mass and libido. However, like any medical treatment, TRT can come with potential side effects. It’s essential to be informed about these side effects, understand why they occur, and know when to contact your doctor. In this blog post, we’ll explore some common and rare side effects of TRT and provide insights into why they may happen.

Hair Loss (Baldness): One of the most frequently reported side effects of TRT is hair loss, which can manifest as male pattern baldness. The key player in this process is dihydrotestosterone (DHT), a hormone derived from testosterone. Therefore, when on a TRT the DHR will start to rise constitutively, when DHT levels in the scalp rise, it binds to receptors in the hair follicles’ cells. This binding triggers a series of cellular processes that disrupt the normal growth cycle of the hair. The hair growth cycle consists of three phases: anagen (growth), catagen (transitional), and telogen (resting). DHT shortens the anagen or growth phase. As a result, the hair spends less time growing and more time resting, leading to shorter and thinner hair strands. 

The specific pattern of hair loss seen in male pattern baldness is a result of the varying sensitivity of hair follicles across the scalp. Hair follicles at the front and top of the head tend to be more sensitive to DHT, while those on the sides and back of the head are less affected, which is why these areas often retain thicker hair. It’s important to note that not all individuals with high levels of DHT will experience male pattern baldness. Genetics plays a significant role in determining susceptibility to hair loss. Additionally, other factors, such as age, hormones, and overall health, can influence the onset and progression of baldness.

Acne: An increase in testosterone levels can stimulate the sebaceous glands in the skin, leading to heightened sebum (oil) production. Excess sebum, when combined with dead skin cells and bacteria, can clog hair follicles and pores, creating an environment conducive to acne formation. While not everyone on TRT will develop acne, the likelihood varies among individuals and may depend on factors such as genetics, dosage, and hormonal balance.

Cardiac Effects: TRT can affect cardiovascular health. While some studies have suggested that TRT may increase the risk of heart problems, others have found no such link. It’s crucial to discuss your cardiac risk factors with your healthcare provider before starting TRT.

Sperm Production: When individuals undergo TRT, they receive exogenous (external) testosterone to raise their testosterone levels. While TRT can offer numerous benefits, it can also have implications for sperm production:

  • TRT can lead to the suppression of the body’s natural testosterone production. When the body senses an influx of testosterone from external sources, it may reduce or even shut down its production of this hormone.
  • Because testosterone is a key hormone in the process of spermatogenesis, a significant increase in exogenous testosterone can disrupt the delicate hormonal balance required for sperm production. As a result, the production of sperm may decrease, leading to a condition known as oligospermia (reduced sperm count) or azoospermia (absence of sperm).

Fertility Concerns and Sperm Production

If you are considering TRT and have concerns about fertility, it’s important to discuss these with your healthcare provider. Here are some important points to consider:

  • Timing: Fertility concerns are most relevant for men who wish to have children in the future. If fertility preservation is a priority, discuss it with your healthcare provider before starting TRT.
  • Alternative Treatments: Depending on your specific situation, your healthcare provider may explore alternative treatment options that do not suppress natural testosterone production. These alternatives can allow you to maintain or even improve sperm production while still benefiting from TRT.
  • Temporary vs. Permanent Impact: For some individuals, the suppression of sperm production while on TRT may be reversible once treatment is discontinued. However, in others, the impact on sperm production may be more persistent or even permanent.
  • Monitoring: Regular monitoring of hormone levels, including testosterone and sperm count, is essential when undergoing TRT. This allows healthcare providers to adjust the treatment plan if needed.

When to Contact Your Doctor

It’s crucial to maintain open communication with your healthcare provider while on TRT. Contact your doctor if you experience any of the following:

  • Severe Hair Loss: If hair loss is significantly affecting your self-esteem or is accompanied by scalp discomfort, discuss potential solutions with your doctor.
  • Persistent or Severe Acne: If acne becomes troublesome or painful, your healthcare provider can recommend skincare products or even adjust your TRT regimen.
  • Cardiac Symptoms: If you experience chest pain, shortness of breath, or any cardiac symptoms while on TRT, seek medical attention immediately.
  • Fertility Concerns: If you plan to father children or are experiencing changes in your fertility, consult your doctor to explore options or temporarily halt TRT.

Remember that side effects can vary from person to person, and not everyone will experience them. Your healthcare provider will work with you to monitor your progress and adjust your treatment plan as needed.

In conclusion, while TRT can bring about numerous benefits, understanding the potential side effects is crucial. Knowing when to contact your doctor and addressing concerns promptly can help you navigate your TRT journey safely and effectively. Please remember that TRT programs go beyond just prescriptions and testing total testosterone and must include an array of scheduled testing (beyond just Testosterone) and continuous consultations. Always consult with a healthcare professional for personalized advice and guidance on TRT.

If you would like to learn more about our TRT program and how it can benefit you, we invite you to schedule a complimentary consultation with our team. During this consultation, we will provide you with detailed information about the program and answer any questions you may have. To book your consultation, please click here.

For added convenience, we also offer the option of a home visit. Our team can visit you in the comfort of your own home to check your eligibility for the program and address any concerns you may have. To schedule a home visit, please click here.

We are committed to helping you unlock your full potential through our TRT program and look forward to assisting you on your journey to hormonal optimization.


  1. Velázquez M, E., & Arata, G. B. (1998). Testosterone replacement therapy. Archives of andrology, 41(2), 79-90. 
  2. Rhoden, E. L., & Morgentaler, A. (2004). Risks of testosterone-replacement therapy and recommendations for monitoring. New England Journal of Medicine, 350(5), 482-492. 
  3. Patel, A. S., Leong, J. Y., Ramos, L., & Ramasamy, R. (2019). Testosterone is a contraceptive and should not be used in men who desire fertility. The world journal of men’s health, 37(1), 45-54. 

Need Help?

Our GluCare Team is always ready to assist.

   800GluCare (+971 4 220 1570)
   Whatsapp us

Social Share

Social Share